How Long Does Cotinine Stay in Your Blood?
How Long Does Cotinine Stay in Your Blood?
Cotinine is a biomarker of nicotine exposure, and it can be used to assess recent smoking history. Cotinine's half-life in blood is about 20 hours, meaning it takes about 20 hours for the concentration of cotinine in your blood to decrease by half.
How Long Cotinine Stays in Your Blood:
| Cotinine Concentration (ng/mL) | Time After Last Cigarette |
|---|---|
| 10 | 1 hour |
| 5 | 2 hours |
| 2.5 | 4 hours |
| 1.25 | 8 hours |
How Long Cotinine Stays in Your Urine:
| Cotinine Concentration (ng/mL) | Time After Last Cigarette |
|---|---|
| 1000 | 1 hour |
| 500 | 2 hours |
| 250 | 4 hours |
| 125 | 8 hours |
After you quit smoking, cotinine levels in your blood and urine will gradually decline. The table below shows how long it takes for cotinine levels to reach 50% of their peak value after you quit smoking.
How Long It Takes for Cotinine Levels to Reach 50% of Peak Value After Quitting Smoking:
| Biomarker | Time After Quitting |
|---|---|
| Blood Cotinine | 20 hours |
| Urine Cotinine | 40 hours |
Cotinine levels can be used to verify smoking cessation and to monitor relapse. If you are trying to quit smoking, your doctor may recommend that you have your cotinine levels tested to track your progress.
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